Last edited by Voodoorg
Wednesday, April 15, 2020 | History

2 edition of Molecular Approaches to Heart Failure Therapy found in the catalog.

Molecular Approaches to Heart Failure Therapy

  • 174 Want to read
  • 19 Currently reading

Published by Steinkopff-Verlag Darmstadt .
Written in English

  • Cardiovascular medicine,
  • Physical Medicine & Rehabilitation,
  • Molecular Genetics,
  • Therapy For Cardiovascular Disorders,
  • Medical,
  • Medical / Nursing,
  • Science,
  • Biochemistry,
  • Cardiology,
  • Heart failure,
  • Medical / Cardiology,
  • molecular approaches to heart failure,
  • myocardial gene transfer techniques,
  • pathophysiology in heart failure,
  • Life Sciences - Genetics & Genomics

  • Edition Notes

    ContributionsG. Hasenfuss (Editor), E. Marban (Editor)
    The Physical Object
    Number of Pages357
    ID Numbers
    Open LibraryOL9670034M
    ISBN 103798512361
    ISBN 109783798512368

      In this regard, 68Ga-FAPI PET has emerged as an important tool for the detection of fibrotic processes in the efforts to improve heart failure therapy," Varasteh said.   Pyramid chart showing the hierarchical structure of treatment approaches to heart failure in congenital heart disease. The diagram displays how to weigh different levels of evidence in order to make health-related decisions. Evidence for effective drug therapy in adult congenital heart disease–related heart failure (HF) is : Pastora Gallego, Jose Maria Oliver.

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Molecular Approaches to Heart Failure Therapy Download PDF EPUB FB2

ISBN: OCLC Number: Description: x, pages: illustrations ; 24 cm: Contents: 1. Alterations in excitation-contraction coupling and potential gene therapy targets in failing human hearts / B. Pieske Cardiac overexpression of [beta]-adrenergic receptors / M.J. Lohse, S. Engelhardt Genetic approaches to elucidate the regulatory role of phospholamban.

Molecular Approaches to Heart Failure Therapy. Editors: Hasenfuss, G., Marban, E. (Eds.) Free Preview. Buy this book eB08 € price for Spain (gross) Buy eBook ISBN ; Digitally watermarked, DRM-free About this book.

This second edition of Dr. Katz's highly acclaimed text has been thoroughly revised to incorporate the latest advances in the study and treatment of heart failure.

The book explains the pathophysiology, molecular mechanisms, clinical manifestations, and therapy of heart failure in an integrated, reader-friendly manner that is accessible to both. Written by recognized leaders in the field, Congestive Heart Failure, Third Edition is a comprehensive, state-of-the-art reference on all basic and clinical aspects of heart failure.

Coverage includes an entire section on pharmacologic therapy and a twenty-chapter section on clinical approaches to acute and chronic heart failure. This edition has new chapters on impact and treatment of. Heart failure is a paradigm case for quality improvement efforts.

Heart failure is common and leads to high morbidity and mortality, as well as high costs of health care. In addition, there are many evidence-based lifestyle modifications and medical therapies for heart failure that. International experts discuss the role of genetics in cardiovascular disease the molecular basis of ischemic disease, thrombosis and hypertension genetic mapping approaches to inherited disorders biologically targeted agents for hypertension and heart failure and much more.

Abundant figures and tables illustrate key concepts. Heart Failure (HF) is the final and common pathway of all cardiovascular diseases. Heart Failure: Bench to Bedside helps address a significant need to develop new paradigms and to identify novel therapeutic targets for this pervasive disease.

This issue of Heart Failure Clinics examines the pharmacologic approaches to heart failure: optimizing established therapy with a look toward future agents. Topics include the pathophysiologic foundation for the pharmacologic treatment of heart failure, t. The book explains the pathophysiology, molecular mechanisms, clinical manifestations, and therapy of heart failure in an integrated, reader-friendly manner that is accessible to both clinicians and basic scientists.

More than illustrations, most created for. Get this from a library. Heart failure: pathophysiology, molecular biology, and clinical management. [Arnold M Katz; Marvin A Konstam] -- This Second Edition of Dr. Katz's text has been thoroughly revised to incorporate the latest advances in the study and treatment of heart failure.

The book explains the pathophysiology, molecular. Gene Therapy in Heart Failure. Human gene therapy is one of the promising approaches in treatment of genetic diseases and rapid development of molecular genetic methods is bringing this.

Heart failure (HF) is a heterogeneous clinical syndrome which may be characterized by a variety of phenotypic changes, many of which have been linked to abnormalities in the intracellular calcium(Ca2+) signal.

These range from mechanical dysfunction, usually characterized by reduced systolic contractile function, to electrophysiological dysfunction Molecular Approaches to Heart Failure Therapy book QT interval prolongation, an.

Pathological molecular mechanisms involved in myocardial remodeling contribute to alter the existing structure of the heart, leading to cardiac dysfunction. Among the Molecular Approaches to Heart Failure Therapy book signaling network that characterizes myocardial remodeling, the distinct processes are myocyte loss, cardiac hypertrophy, alteration of extracellular matrix homeostasis, fibrosis, defective autophagy, metabolic Cited by: The Molecular Cardiology program is the study of genetic heart disorders.

Our major goal is to reduce human disease by combining basic science research and clinical cardiology. Our research is about saving lives because we know that many cardiovascular conditions caused by underlying genetic faults. In Molecular Cardiology: Methods and Protocols, leading cardiac researchers from around the world describe in detail their own proven, cutting-edge techniques for gene therapy and stem cell therapy for heart diseases.

The authors provide readily reproducible methods for genetic dissection, signal transduction, and microarray analysis. In these studies, selective heart rate reduction with ivabradine added to beta-blockers further reduced remodelling and improved EF.

55–57 Heart-rate reduction also decreases energy expenditure (which is increased by positive inotropes) as shown by higher energy phosphate availability. 58 In addition to slowing the heart rate, beta-blockers Cited by: 6.

Atlas of Heart Failure will further explore the impressive strides that have been made in the pathophysiology of heart failure at all levels, including molecular changes and the integrated circulatory system. This edition will provide a current overview of normal cardiac function and approaches that can be used to manage the system.

Understanding of contemporary pharmacological therapy for chronic heart failure continues to evolve. In this Review, we discuss how findings from clinical trials have caused the roles of old therapies to be expanded and past treatment algorithms to be challenged. Several trials investigating preserved ejection fraction as a measure of heart failure had disappointing results, although important Cited by: Product Information.

A comprehensive reference on various basic and clinical aspects of heart failure. This title covers information on genetics, surgical therapies, ventricular synchronization, defibrillator therapy, mechanical approaches to atrial fibrillation, ventricular support and ventricular remodeling surgery, and myocardial regeneration/cell transplantation.

Contents: 1. Alterations in excitation-contraction coupling and potential gene therapy targets in failing human hearts / B. Pieske -- 2. Cardiac overexpression of [beta]-adrenergic receptors / M.J.

Lohse, S. Engelhardt -- 3. Genetic approaches to elucidate the regulatory role of phospholamban in the heart / A.G. Schmidt, E.G. Kranias -- 4. Book. Principles of Echocardiography and Intracardiac Echocardiography Percutaneous Approaches to Valvular Heart Disease, An Issue of Interventional Cardiology Clinics.

Samin Sharma. Apr Stage B, A Pre-cursor to Heart Failure, Part II, An Issue of Heart Failure Clinics. Jay Cohn. Mar Despite major improvements in the treatment of virtually all cardiac disorders, heart failure (HF) is an exception, in that its prevalence is rising, and only small prolongations in survival are occurring.

An increasing fraction, especially older women with diabetes, obesity, and atrial fibrillation exhibit HF with preserved systolic function. Several pathogenetic mechanisms appear to be.

Describe guideline-directed medical therapy (GDMT) for patients with heart failure, including the role of newer agents. Outline the pharmacist’s role on an interprofessional team caring for patients with heart failure.

Using case scenarios, illustrate key considerations in providing interprofessional care to patients with heart failure. Novel Strategies and Approaches in Hypertension Therapy introduces the reader to different aspects of hypertension treatment (environmental and occupational factors and different clinical settings that can trigger the disease).

The book also covers special topics related to the use of new diagnostic biomarkers for hypertension patients, as well Author: Hafize Uzun Pınar Atukeren, Abdulhalim Senyigit, Aykut Oruc, Berrin Papila Kundaktepe, Bahadir Simse.

Systematic study of heart failure in children began in earnest in the midth century. The most common cause of pediatric heart failure remained rheumatic fever, 5 but in the s the novel concept that congenital heart disease disproportionately caused heart failure in infancy began to gain currency.

6 This finding, reported in multiple series, 7–10 contributed a unique pediatric Cited by: Heart Failure With Reduced EF. During the past 30 years, HFrEF has evolved from a rapidly fatal disease to a chronic condition requiring long-term team management ().Improved survival has been documented in symptomatic HF from outpatient populations, 4 – 6 in patients discharged from hospitalization, 7,8 and for patients after referral for advanced therapies.

9,10 The threat of sudden death Cited by:   Emerging Technologies for Heart Diseases was conceived to cover the recent extensive literature on current and novel therapeutic options for cardiac patients. The first volume is dedicated to heart failure and valvular disorders, and the second covers myocardial ischemia and arrhythmias.

Gene therapy approaches to cardiac neovascularization Book Edition: 1. Subjective Evaluations of Alcohol Consequences and Changes in Drinking Behavior 4.

Predicting Marital Separation From Parent-Child Relationships 5. Positive Effects of the Mediterranean Diet in the Prevention and Management of Cardiovascular Disease Quantitative Literature Reviews 6. Dance Therapy in Patients With Chronic Heart Failure 7. Hurst’s the Heart, 14th Edition (): Chapter 6, Molecular and Cellular Biology of the Heart Roger J.

Hajjar, Kiyotake Ishikawa, and Thomas Thum; Methods in molecular biology () Ishikawa K, Hajjar RJ. Current Methods in Cardiac Gene Therapy: Overview. Methods in molecular biology () Del Monte F, Ishikawa K, Hajjar RJ. Advances in Heart Failure Management. we are witnessing the beginning of the molecular revolution that will influence every aspect of heart failure care.

This book of thirteen chapters from. Contents: Definition, historical aspects -- The failing heart as a damaged pump -- The neurohumoral response in heart failure: functional signaling -- The hypertrophic response in heart failure: proliferative signaling -- Cellular and molecular abnormalities in the failing heart -- Therapeutic options for patients with, or at risk for, heart.

Heart failure is considered an epidemic disease in the modern world affecting approximately 1% to 2% of adult population. It presents a multifactorial, systemic disease, in which–‐after cardiac injury‐–structural, neurohumoral, cellular, and molecular mechanisms are activated and act as a network to maintain physiological by: Elucidating the underlying molecular mechanisms and functional consequences of ion channel remodeling at the cellular and organ levels presents a unique opportunity for the development of novel pharmacological, device, gene, and cell based approaches for the treatment of arrhythmias in heart failure.

Electrophysiological remodeling in heart Author: Fadi G. Akar, Gordon F. Tomaselli. And Harvard Medical School Researchers Team Up On Molecular Therapy For Heart Failure Published: CAMBRIDGE, Mass., Nov. 9 /PRNewswire/ -- Nearly five million Americans have congestive heart failure, half of which is classified as non-ischemic heart failure.

Title: Editorial [Hot Topic: Novel Pharmacological Therapies for Cardiac Hypertrophy and Heart Failure (Executive Guest Editor: Peter M. Kang)] VOLUME: 17 ISSUE: 18 Author(s):Peter M. Kang Affiliation:Cardiovascular Institute, Beth Israel Deaconess Medical Center, 3 Blackfan Circle, CLSBoston, MA Author: Peter M.

Kang. Despite advances in the management of heart failure (HF), a significant burden of mortality and morbidity remains. 1 This, combined with the ever-escalating costs of novel drug development, has led to an increased focus on the treatment of comorbidities in order to improve outcomes.

As a chronic condition, it is increasingly recognised that HF is actually an iron-deficient Cited by: Congestive heart failure (CHF) is a complex clinical syndrome that can result from any functional or structural cardiac disorder that impairs the ventricle’s ability to fill with or eject blood.

Since there is no definitive diagnostic test for heart failure, it remains a clinical diagnosis that is. The book has five major sections that cover the epidemiology and economics of heart failure and benchmarks for the assessment of therapy, medical therapies, conventional surgical approaches, cardiac transplantation and left ventricular assist devices, and novel surgical therapies such as ventriculectomy and dynamic : $ Chronic Heart Failure National Clinical Guideline for Diagnosis and Management in Primary and Secondary Care.

This book offers the best practice advice on the care of adult patients (aged 18 years or older) who have symptoms or a diagnosis of chronic heart failure.

Objectives This study examined the relationship between income inequality and heart failure outcomes. Background The income inequality hypothesis postulates that population health is influenced by income distribution within a society, with greater inequality associated with worse outcomes.

Methods This study analyzed heart failure outcomes in 2 large trials conducted in 54 Cited by:. Journal of Cardiovascular Diseases & Diagnosis is an Open Access scholarly, academic journal that is concerned with both basic and translational research, across different disciplines and areas, enhancing insight in cardiovascular disease mechanisms and the perspective for innovation.

Unparalleled in its scope and depth, this book brings together proteomic approaches in diagnosis and treatment from all clinical fields, including clinical toxicology. The result is a new discipline in molecular medicine that will revolutionize the treatment and prevention of cancer, stroke and other severe diseases.Previous Distinguished Scientist Recipients.

The American Heart Association/ American Stroke Association's Distinguished Scientists was created in to recognize AHA/ASA members for significant, original and sustained scientific contributions that have advanced the association's mission: "To be a relentless force for a world of longer, healthier lives.".